期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 48, 期 13, 页码 4204-4207出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm040224i
关键词
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We report a three-dimensional model of the alpha 5 beta 1 integrin headgroup bound to the most potent and selective ligand (SJ749) known to date. The model was built using the comparative protein modeling method, and it is consistent with experimental data. From this study, we identified two potentially important regions in the alpha 5 beta 1 receptor that are peculiar to this integrin and might be worth considering for drug targeting.
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