期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 48, 期 13, 页码 4208-4211出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm050267e
关键词
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A series of 1-acyl-1H-[1,2,4]triazole-3,5-diamine analogues were synthesized as cyclin-dependent kinase (CDK) inhibitors. These compounds showed potent and selective CDK1 and CDK2 inhibitory activities and inhibited in vitro cellular proliferation in various human tumor cells. Representative compound 3b demonstrated in vivo efficacy in a human melanoma A375 xenograft model in nude mice.
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