期刊
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
卷 193, 期 1, 页码 64-70出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2004.12.088
关键词
muscle damage; levator ani muscle
Objective: Studies in animals and human muscle have demonstrated differential splicing of the insulin-like growth factor-1 gene in response to mechanical strain and damage. We conducted a study on the expression of insulin-like growth factor-1 splice variants in the levator am muscle after the first vaginal delivery. Study design: Ten women were recruited after the first vaginal delivery. Biopsy specimens were taken vaginally of the pubovisceral component of the levator am muscle. Five nonpregnant women were recruited as control subjects. Samples were processed with real-time quantitative polymerase chain reaction, with specific primers for the insulin-like growth factor-1 splice variants. Results: Insulin-like growth factor splice variants mechano growth factor and insulin-like growth factor-1Ea were significantly up-regulated (100- and 1000-fold) in the delivery population, compared with control subjects (P = .012 and .04, respectively). Statistical analysis indicated a correlation between the expression of the insulin-like growth factor-1 splice variants and the length of the second stage. Conclusion: These results show that damaged levator am muscle results from stretch and overload after the first vaginal delivery. (c) 2005 Elsevier Inc. All rights reserved.
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