期刊
EXPERIMENTAL GERONTOLOGY
卷 40, 期 7, 页码 573-581出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2005.05.001
关键词
muscle mass; sarcopenia; aging; Rhesus monkeys; skeletal muscle
资金
- NCRR NIH HHS [P51 RR000167, RR15459-01, RR020141-01] Funding Source: Medline
- NIA NIH HHS [AG-11915] Funding Source: Medline
Sarcopenia, the decline in skeletal muscle mass and function with age, contributes to increased frailty and decreased functional performance in the aging human population. The negative health consequences of muscle mass loss emphasize the need for development of a nonhuman primate model for the prevention or attenuation of sarcopenia. The age of onset for muscle mass loss in Rhesus macaques was determined using three datasets; (i) dual-energy X-ray absorptiometry (DXA) data from a cross-sectional study of 90 adult Rhesus monkeys; (ii) lean tissue mass and estimated skeletal muscle mass (ESM) from 727 DXA scans taken in 38 monkeys in a long-term, longitudinal aging study; and, (iii) quadriceps weights taken at necropsy from 13 male and 28 female Rhesus monkeys. These data indicate that both male and female Rhesus monkeys develop sarcopenia with age. The onset of sarcopenia is 14.1 +/- 2.8 years in females and 15.8 +/- 2.5 years in males. Muscle loss reaches 20% in males by 23.2 years of age and in females by 24.5 years of age. Furthermore, our data indicate percentage declines in ESM similar to those seen in humans with advancing age. These data support the suitability of the Rhesus monkey as a primate sarcopenia model. (c) 2005 Elsevier Inc. All rights reserved.
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