期刊
ANNALS OF NEUROLOGY
卷 58, 期 1, 页码 151-155出版社
WILEY
DOI: 10.1002/ana.20523
关键词
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资金
- NCRR NIH HHS [K23 RR16281-01, M01-RR00084, RR011126, M01-RR02035-01] Funding Source: Medline
We tested the efficacy and safety of glutamine (0.6gm/kg/day) and creatine (5gm/day) in 50 ambulant boys with Duchenne muscular dystrophy in a 6-month, double-blind, placebo-controlled clinical trial. Drug efficacy was tested by measuring muscle strength manually (34 muscle groups) and quantitatively (10 muscle groups). Timed functional tests, functional parameters, and pulmonary function tests were secondary outcome measures. Although there was no statistically significant effect of either therapy based on manual and quantitative measurements of muscle strength, a disease-modifying effect of creatine in older Duchenne muscular dystrophy and creatine and glutamine in younger Duchenne muscular dystrophy cannot be excluded. Creatine and glutamine were well tolerated.
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