期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 164, 期 1-2, 页码 93-104出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2005.04.004
关键词
Th1/Th2 cells; cell surface molecules; experimental autoimmune encephalomyelitis; real-time quantitative RT-PCR; TCRBV8S2(+) tcells
Expression of T cell immunoglobulin- and mucin-domain-containing molecules (TIMs) can be used as T helper (Th) differentiation markers in the human and mouse. We examined the expression of TIM-1 and -3 mRNAs in rat MBP63-88-induced experimental autoimmune encephalomyelitis (EAE). TIM-3 expression was upregulated in the spinal cord during EAE and following antigen restimulation of the encephalitogenic TCRBV8S2(+) population. Interestingly, TIM-3 expression was also detected by in situ hybridization in resident cells of the nervous system. TIM-1 was expressed in B cells but not in resident CNS cells and TIM-1 mRNA levels in spinal cord were unchanged throughout the course of EAE. These results support the notion that TIM-3 can also be used as a Th1 differentiation marker in the rat. However, expression of TIM-1 and -3 is not restricted solely to T cells and the presence of TIM-3 in resident CNS cells may indicate a role for this molecule in the interaction between the nervous and immune systems. (C) 2005 Elsevier B.V. All rights reserved.
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