期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 6, 期 7, 页码 555-566出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1679
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A unique family of protein kinases has evolved with regulatory domains containing sequences that are related to Ca2+-binding EF-hands. In this family, the archetypal Ca2+-dependent protein kinases (CDPKs) have been found in plants and some protists, including the malarial parasite, Plasmodium falciparum. Recent genetic evidence has revealed isoform-specific functions for a CDPK that is essential for Plasmodium berghei gametogenesis, and for a related chimeric Ca2+ and calmodulin-dependent protein kinase (CCaMK) that is essential to the formation of symbiotic nitrogen-fixing nodules in plants. In Arabidopsis thaliana, the analysis of 42 isoforms of CDPK and related kinases is expected to delineate Ca2+ signalling pathways in all aspects of plant biology.
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