Association between alletic variants in cytokine genes and preectampsia

Objective: The purpose of this study was to examine the relationship between cytokine genotypes and preeclampsia. Study design: We conducted a case-control study that examined cytokine genotypes among 150 primiparous preeclamptic women and 661 primiparous, normotensive women. Analyses were adjusted for age, prepregnancy cigarette smoking, and education. Results: Preeclamptic white women were more likely than normotensive white women to carry the up-regulating tumor necrosis factor-alpha-308 A/A (odds ratio, 4.1; 95 % Cl, 1.1-15.3) genotype. Both black and white women with preeclampsia were more likely than normotensive control subjects to carry the interleukin-1 alpha-producing-4845 G/G genotype (black odds ratio, 11.6; 95% Cl, 1.5-89.3; white odds ratio, 1.7; 95% Cl, 0.7-3.9), -889 C/C genotype (black odds ratio, 5.1; 95% CI, 0.6-41.6; white odds ratio, 1.9; 95% Cl, 0.8-4.7), and the interleukin-1 alpha-4845/ interleukin-1 alpha-889/interteukin-1 beta-3957 GCC/GCC haplotype (black odds ratio, 3.4; 95% Cl, 1.3-8.7; white odds ratio, 2.1; 95% Cl, 1.4-3.2). Conclusion: Cytokine genotypes were associated with preeclampsia and may identify women who are at high risk for preeclampsia. (c) 2005 Elsevier Inc. All rights reserved.