期刊
CLINICAL INFECTIOUS DISEASES
卷 41, 期 -, 页码 S38-S44出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/429494
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资金
- NIDA NIH HHS [R01 DA013799-01A1, DA-13799, R01 DA013799] Funding Source: Medline
- NIMH NIH HHS [MH-58552, R01 MH058552, T32 MH019535, R01 MH058552-02] Funding Source: Medline
Infection with hepatitis C virus (HCV) is commonly seen in persons with human immunodeficiency virus (HIV) infection, because the viruses share risk factors for transmission; coinfection is a leading cause of morbidity and mortality among HIV-infected persons. Neuropsychological consequences of HIV infection are well established, and studies of HCV-infected persons have revealed neuropsychiatric dysfunction in this population as well. Investigators now are focusing on neuropsychological sequelae of coinfection with HIV and HCV, and preliminary results suggest that coinfection has a possible deleterious effect on global cognitive functioning consistent with frontal-subcortical dysfunction. Data on neuropsychiatric symptoms in coinfected persons are inconclusive at this time and are complicated by important differences in study populations (e. g., injection drug use and disease severity). This review summarizes what is known about neuropsychological aspects of monoinfection with HIV and HCV, as well as coinfection, discusses implications of these findings, and suggests future directions for this research area.
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