期刊
JOURNAL OF NEUROSCIENCE RESEARCH
卷 81, 期 1, 页码 45-52出版社
WILEY
DOI: 10.1002/jnr.20522
关键词
FOXP3; Treg cells; multiple sclerosis
资金
- NIAID NIH HHS [AI48779] Funding Source: Medline
- NINDS NIH HHS [NS23444, NS41965, NS23221] Funding Source: Medline
Autoimmune diseases such as multiple sclerosis (MS) may result from the failure of tolerance mechanisms to prevent expansion of pathogenic T cells. Our study is the first to establish that MS patients have abnormalities in FOXP3 message and protein expression levels in peripheral CD4(+)CD25(+) T cells (Tregs) that are quantitatively related to a reduction in functional suppression induced during suboptimal T-cell receptor (TCR) ligation. Of importance, this observation links a defect in functional peripheral immunoregulation to an established genetic marker that has been unequivocally shown to be involved in maintaining immune tolerance and preventing autoimmune diseases. Diminished FOXP3 levels thus indicate impaired immunoregulation by Tregs that may contribute to MS. Future studies will evaluate the effects of therapies known to influence Treg cell function and FOXP3 expression, including TCR peptide vaccination and supplemental estrogen. (c) 2005 Wiley-Liss, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据