Antimycins A10∼A16, seven new antimycin antibiotics produced by Streptomyces spp. SPA-10191 and SPA-8893

Seven new antimycin antibiotics, named antimycins A(10), A(11), A(12), A(13), A(14), A(15) and A(16), were isolated from the fermentation broth of strains of Streptomyces spp. SPA-10191 and SPA-8893, along with known antimycins A(1), A(2), A(3) and A(4). The structures of the new antimycins were determined by spectral analyses, including 2D NMR techniques. These compounds exhibited antifungal activity against Candida utilis.