期刊
NEUROBIOLOGY OF AGING
卷 26, 期 7, 页码 1023-1028出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2004.09.016
关键词
Alzheimer's disease; Alzheimer model; neuropathology; amyloid- beta-peptide; APP; Octodon degu
It is generally accepted that human Alzheimer's disease (AD) neuropathology markers are completely absent in rodent brains. We report here that an aged wild-type South American rodent, Octodon degu, expresses neuronal beta-amyloid precursor protein (beta-APP695) displaying both intracellular and extracellular deposits of amyloid-beta-peptide (A beta), intracellular accumulations of tau-protein and ubiquitin, a strong astrocytic response and acetylcholinesterase (AChE)-rich pyramidal neurons. The high amino acid homology (97.5%) between deguA beta and humanA beta sequences is probably a major factor in the appearance of AD markers in this aged rodent. Our results indicate that aged 0. degu constitutes the first wild-type rodent model for neurodegenerative processes associated to AD. (c) 2004 Elsevier Inc. All rights reserved.
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