期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 62, 期 13, 页码 1409-1417出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-005-5100-9
关键词
intrinsically unstructured proteins; RNA-binding proteins; RNA chaperones; human immunodeficiency virus; NCp7; fragile X mental retardation; FMRP; prion diseases
RNA chaperones are ubiquitous proteins that play pivotal roles in cellular RNA metabolism and RNA virus replication. Here we propose that they act by organizing complex and highly dynamic networks of RNA-RNA, RNA-protein and protein-protein interactions. How this is achieved and how their malfunction may lead to disease will be discussed through the examples of human immunodeficiency virus type 1 nucleocapsid protein (NCp7), the fragile X mental retardation protein and the prion protein.
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