期刊
STEROIDS
卷 70, 期 8, 页码 487-493出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2005.01.001
关键词
Sinularia dissecta; poiyhydroxylated steroids; dissectolide
A repeated silica gel column chromatography followed by HPLC purification on the methanol extract of marine soft coral Sinularia dissecta, resulted in the isolation of fifteen polyhydroxylated steroids (1-15), involving six new C- 18 functionalized steroids, 3 beta-acetoxy-1 alpha, 11 alpha-dihydroxygorgost-5-en- 18-oic acid (1), gorgost-5-en-1 alpha,3 beta,11 alpha, 18-tetrol (2), 18-acetoxy-1 alpha,3 beta, 11 alpha-trihydroxygorgost-5-ene (3), 24(S)-3 beta-acetoxy- 1 alpha, 11 alpha-dihydroxyergost-5-en- 18-oic acid (4), 24(S)-ergost-5-en- 1 alpha,3 beta, 11 alpha, 18-tetrol (5), and dissectolide (6). The structures of the new compounds were determined on the basis of extensive spectroscopic data (IR. MS, (1)H and (13)C NMR, HMQC, HMBC, and NOESY) analysis. Compound 6 was found as an unusual sterol bearing a lactone functionality. (c) 2005 Elsevier Inc. All rights reserved.
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