期刊
AUTOIMMUNITY REVIEWS
卷 4, 期 6, 页码 351-363出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2005.01.007
关键词
regulatory T cells; CD4+CD25+ T cells; Tr1; Th3; multiple sclerosis; rheumatoid arthritis; myasthenia gravis; autoinimune polyglandular syndrome type II; type 1 diabetes; autoimmune lymphoproliferative syndrome; Kawasaki disease; systemic lupus erythematosus
类别
The crucial role of regulatory cells in self-tolerance and autoimmunity has been clearly established in numerous types of regulatory cells, the majority of which are CD4(+)T cells. Much focus has been placed on thymically derived CD4(+)CD25(+) regulatory T cells, given that the depletion of this subset in murine models results in the spontaneous development of autoimmune diseases. These naturally occurring regulatory T cells are found to be functionally mature in the thymus, and exert suppression in a contact-dependent manner. Another important category of immunosuppressive cells consists of conditionally induced regulatory T cells such as Tr1, Th3, and various other CD4(+) lymphocytes. Understanding the development and regulatory functions of immunoregulatory cells may elucidate the etiology for loss of self-tolerance. This review will summarize the characteristics, developmental pathways, and functions of regulatory T cells, as well as their role in human autoimmune diseases including multiple sclerosis, rheumatoid arthritis, Myasthenia Gravis, Kawasaki disease, autoimmune polyglandular syndrome type II, type I diabetes, autoimmune lymphoproliferative syndrome, and systemic lupus erythematosus. (c) 2005 Published by Elsevier B.V.
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