期刊
NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY
卷 2, 期 7, 页码 308-315出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncpgasthep0215
关键词
Crohn's disease; inflammation; inflammatory bowel disease; ulcerative colitis; vitamin D
Until recently, 1,25-dihydroxyvitamin D-3 (1,25(OH)(2)D-3)-the active form of vitamin D-was thought to function primarily as a regulator of calcium and phosphate metabolism. More diverse functionality was indicated by the discovery of the vitamin D receptor in tissues that are not involved in calcium and phosphate homeostasis. Detection of the vitamin D receptor in monocytes and activated T cells has sparked interest in the immunomodulatory properties of vitamin D. Here, we review the role of vitamin D in regulation of the immune system, and evidence for its involvement in the pathogenesis of inflammatory bowel disease.
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