期刊
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
卷 175, 期 1, 页码 43-64出版社
SPRINGER
DOI: 10.1007/s12010-014-1256-9
关键词
3-acetyl quinolones; 4-hydroxy-3-(3-arylacryloyl)quinolin-2(1H)-ones; 3-(4,5-dihydro-5-aryl-1-phenyl-1H-pyrazol-3-yl)-4-hydroxyquinolin-2(1H)-ones; Antimicrobial, in silico antimalarial activities
A few derivatives of 3-(4,5-dihydro-5-aryl-1-phenyl-1H-pyrazol-3-yl)-4-hydroxyquinolin-2(1H)-ones (5a-j) that are synthesized from 4-hydroxy-3-(3-arylacryloyl)quinolin-2(1H)-ones (4a-j) by microwave-assisted synthesis are screened for their antimicrobial, in silico antimalarial activities. Among the tested compounds 4h and 5d were found to have a potent antimalarial activity than the standards, and the others are found to show considerable antimalarial activity and moderate antimicrobial activity.
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