期刊
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
卷 174, 期 7, 页码 2446-2457出版社
HUMANA PRESS INC
DOI: 10.1007/s12010-014-1192-8
关键词
Nymphaea rubra; Nymphaeaceae; Insulin resistance; TNF-alpha; L6 myotubes; Glucose uptake; Insulin signaling
资金
- CSIR Biodiscovery, New Delhi, India [BSC-0120]
- ICMR
- CSIR, New Delhi, India
In this work, we demonstrated insulin signaling and the anti-inflammatory effects by the chloroform fraction of ethanolic extract of Nymphaea rubra flowers in TNF-alpha-induced insulin resistance in the rat skeletal muscle cell line (L6 myotubes) to dissect out its anti-hyperglycemic mechanism. N. rubra enhances the GLUT4-mediated glucose transport in a dose dependent manner and also increases the tyrosine phosphorylation of both IR-beta and IRS-1, and the IRS-1 associated PI-3 kinase activity in TNF-alpha-treated L6 myotubes. Moreover, N. rubra decreases Ser(307) phosphorylation of IRS-1 by the suppression of JNK and NF-kappa B activation. In conclusion, N. rubra reverses the insulin resistance by the inhibition of c-Jun NH2-Terminal Kinase and Nuclear-kappa B.
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