期刊
CHEMBIOCHEM
卷 6, 期 7, 页码 1234-1241出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.200400421
关键词
antioxidants; high-throughput screening; immunoassays; natural products; pro-oxidants
A recently reported high-throughput screening strategy has been applied to the rapid selection of new water-soluble antioxidants that display strong protective activities. Based on a competitive immunoassoy, a triple-screening procedure was used to evaluate the ability of different compounds to protect thymidine under different oxidative stresses. The pro-oxidant effect of norbadione A in the presence of iron was observed, while some pulvinic acid derivatives proved strongly protective during gamma radiolysis, UV irradiation, and Fenton-like oxidation.
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