期刊
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
卷 60, 期 2, 页码 167-178出版社
ELSEVIER
DOI: 10.1016/j.ejpb.2005.03.004
关键词
reconstructed human epidermis; lipid composition; biochemical markers; drug delivery; skin
The commercially available reconstructed human epidermis models EpiSkin (R), SkinEthic (R) and EpiDerm (R) demonstrate reasonable similarities to the native human tissue in terms of morphology, lipid composition and biochemical markers. These models have been identified as useful tools for the testing of phototoxicity, corrosivity and irritancy, and test protocols have been developed for Such applications. For acceptance of these tests by the authorities, prevalidation or validation Studies are currently in progress. Furthermore, first results also indicate their suitability for transport experiments of drugs and other xenobiotics across skin. Still, however, the barrier function of these reconstructed human epidermis models appears to be much less developed compared to native skin. Further adaptation of the models to the human epidermis, especially concerning the barrier function, therefore remains an important challenge in this area of research. (c) 2005 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据