期刊
NUTRITION RESEARCH
卷 25, 期 7, 页码 701-709出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.nutres.2005.07.004
关键词
rat; liver fat; vitamin E; selenium; DPPD; alcohol; caffeine
We have previously produced a robust model of ethanol addiction in rats using a high-fat, alcohol-containing diet. Substitution of carbohydrate for fat in this diet greatly ameliorated the deleterious effect of alcohol, particularly the accompanying fatty liver. In the present study, we examined the role of certain antioxidants when added to the addictive, high-fat, alcohol-containing diet. Antioxidants such as vitamin E, diphenyl-para-phenylenediamine, and selenium, as well as cranberry powder and soy protein have been shown to prevent oxidative stress that can lead to cell death. The liver is particularly vulnerable to oxidative stress because of excessive fat accumulation subsequent to insults such as high-fat diets and/or alcohol abuse. Because caffeine has been shown to reduce body fat accumulation in mice, this drug was also included in some experiments, either combined with or separate from antioxidant-enriched diets. It was observed that high doses of vitamin E and of selenium significantly increased liver fat accumulation in rats fed the alcohol-containing diet. Diphenyl-para-phenylenediamine combined with caffeine significantly reduced liver fat accumulation. Neither soy protein nor cranberry powder exerted significant effects on the alcohol-induced fatty liver. These observations indicate that high doses of vitamin E and selenium may be deleterious to liver function especially in the presence of high-fat diets and/or alcohol consumption. (c) 2005 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据