期刊
INFLAMMATION RESEARCH
卷 54, 期 7, 页码 295-303出版社
SPRINGER BASEL AG
DOI: 10.1007/s00011-005-1357-6
关键词
Carapa guianensis Aubl.; allergy; pleurisy; edema; hyperalgesia; inflammatory mediators
Objective: We investigated the anti-allergic and analgesic properties of an oil and a derived fraction of tetranortriterpenoids (TNTP) obtained from the seeds of Carapa guianensis Aublet. \ Materials and methods: Pleurisy, paw and ear edema were induced in Swiss and C57/Bl10 mice mice, whereas thermal hyperalgesia was assessed in Wistar rats (n = 6-10 per group). Values of p < 0.05 were regarded as significant. Results: C. guianensis oil (100 to 400 mg/kg, p.o.) and TNTP (12.5 to 100 mg/kg, p. o.) inhibited pleural exudation, paw and ear edema induced by ovalbumin (OVA) in sensitized mice. TNTP (12.5 to 100 mg/kg, p.o.) also inhibited paw edema induced by histamine, FAF and bradykinin. TNTP (100 mg/kg, p. o.) inhibited prostaglandin E, generation in the pleural cavity in response to antigenic challenge. Moreover, C. guianensis oil (100 to 400 mg/kg) and TNTP (12.5 to 100 mg/kg) decreased OVA- and histamine-induced hyperalgesia. Conclusion: Taken together, these findings demonstrate the anti-edematogenic and analgesic effects of C guianensis oil, and points out TNTP as the responsible bioactive compounds.
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