期刊
NEUROBIOLOGY OF AGING
卷 26, 期 7, 页码 995-1000出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2004.09.014
关键词
caloric restriction; AD transgenics; amyloid deposition; astrocyte activation
Dietary influences on Alzheimer disease (AD) are gaining recognition. Because many aging processes are attenuated in laboratory mammals by caloric restriction (CR), we examined the effects of short-term CR in two AD-transgenic mice, APP(swe/ind) (J20) and APP(swe) + PS1(M146L) (APP+PS1), CR substantially decreased the accumulation of A beta-plaques in both lines: by 40% in APP(swe/ind) (CR, 6 weeks), and by 55% in APP + PS1 (CR, 14 weeks). CR also decreased astrocytic activation (GFAP immunoreactivity). These influences of CR on AD-transgenic mice are consistent with epidemiological reports that show that high caloric diets associate with the risk of AD, and suggest that dietary interventions in adult life might slow disease progression. (c) 2004 Elsevier Inc. All rights reserved.
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