3.8 Article

Testing the antagonistic effect of follistatin on BMP family members in ovine granulosa cells

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REPRODUCTION NUTRITION DEVELOPMENT
卷 45, 期 4, 页码 419-425

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EDP SCIENCES S A
DOI: 10.1051/rnd:2005031

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ovary; granulosa cells; follistatin; noggin; bone morphogenetic protein

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Follistatin was first demonstrated as an activin-binding protein, neutralizing its actions. However, there is emerging evidence that follistatin inhibits the action of other members of the transforming growth factor beta (TGF beta)/bone morphogenetic protein (BMP) superfamily. Recently, numerous BMP factors have been shown to play important roles in regulating folliculogenesis and ovulation rate in mammals, and such a potential antagonistic role of follistatin is of particular interest in the context of ovarian function. Using a biological test based on progesterone production by ovine primary granulosa cells in culture, we show that follistatin was a strong antagonist of activin A, but not BMP-2 or BMP-4 actions. In contrast, noggin, a known specific BMP antagonist, had no effect on activin A but strongly neutralized BMP-2 and BMP-4 actions. BMP-6 action was only slightly reduced by both follistatin and noggin. Our data led to the conclusion that follistatin would not represent a determinant physiological modulator of the biological effect of BMP factors on granulosa cells.

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