期刊
TRENDS IN GENETICS
卷 21, 期 7, 页码 370-373出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2005.05.007
关键词
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资金
- Wellcome Trust Funding Source: Medline
RNA interference is a highly conserved pathway mediating sequence-specific RNA degradation. In plants, the short RNA intermediates of this pathway can also drive transcriptional silencing of target genes by DNA methylation. Until recently, there was no evidence that a similar pathway operated in mammals; two new studies suggest that small RNAs can direct DNA methylation and chromatin modification in human cells. Although further investigation is required to determine how widespread RNA-directed DNA methylation is in mammals, the findings raise the possibility that this pathway, far from being merely a curiosity of plant systems, is a conserved mechanism for control of gene expression.
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