A benzoisofuranone derivative and carbazole alkaloids from Murraya koenigii and their antimicrobial activity

A benzoisofuranone derivative, 3 xi-(1 xi-hydroxyethyl)-7-hydroxy-1-isobenzofuranone, and a dimeric carbazole alkaloid, 3,3'-[oxybis(methylene)]bis(9-methoxy-9H-carbazole), along with six known carbazole alkaloids and three known steroids were isolated from the stem bark of Murraya koenigii. The structures of these compounds were established unambiguously by UV, IR, MS and a series of 1D and 2D NMR analyses. The minimum inhibitory concentrations (MIC) of these compounds were found to be in the range 3.13-100 mu g/ml. (c) 2005 Elsevier Ltd. All rights reserved.