期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 99, 期 1, 页码 5-22出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.01405.2004
关键词
autonomic nervous system; sympathetic nervous system; metaboreceptors; mechanoreceptors
资金
- NCRR NIH HHS [C06 RR016499, M01 RR010732] Funding Source: Medline
- NHLBI NIH HHS [R01 HL075533, R01 HL070222, R01 HL060800, P01 HL077670] Funding Source: Medline
In this review we examine the exercise pressor reflex in health and disease. The role of metabolic and mechanical stimulation of thin fiber muscle afferents is discussed. The role ATP and lactic acid play in stimulating and sensitizing these afferents is examined. The role played by purinergic receptors subdivision 2, subtype X, vanilloid receptor subtype 1, and acid-sensing ion channels in mediating the effects of ATP and H(+) are discussed. Muscle reflex activation in heart failure is then examined. Data supporting the concept that the metaboreflex is attenuated and that the mechanoreflex is accentuated are presented. The role the muscle mechanoreflex plays in evoking renal vasoconstriction is also described.
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