期刊
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
卷 62, 期 1, 页码 63-70出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1365-3083.2005.01638.x
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There are differences between children and adults in certain aspects of the Helicobacter pylori (HP) infection, among them the lower titre of IgG antibodies anti-HP in the former group. Thus, we investigated by means of flow cytometry CD4(+)/CD3(+) (CD4(+)T), CD8(+)/CD3(+) (CD8(+)T) and CD19(+)/CD3(-) (B) cells, activation/co-stimulatory markers (CD4(+)/HLA-DR+, CD4(+)/CD28(+), CD8(+)/ HLA-DR+ and CD8(+)/CD28(+)) and by means of ELISA IgG anti-HP antibodies in the peripheral blood from HP-positive and -negative children and adults. An increased CD4(+)/CD28(+) and CD8(+)/CD28(+) percentage and number of CD4(+)/CD3(+) cells were seen in infected adults. Conversely, no difference was observed between infected and noninfected children, but when they were stratified by age, an increased CD4(+)/CD28(+) cell percentage was seen in the HP-positive group older than 10 years. The mean level of IgG anti-HP was lower in younger infected children, increased with age and correlated with CD4(+) cells. Our data suggest that the immune response to HP infection vary according to the age. Low percentage of activated CD4(+) cell may contribute to the lower level of serum IgG anti-HP observed in younger infected children. In addition, the CD4(+) cell participation during the infection seems to begin after 10 years old, when the immune response becomes similar to that seen in adults.
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