The interleukin-6-174G/C promoter polymorphism is not associated with endometriosis in south Indian women

OBJECTIVE: To investigate the association of the - 174 G/C promoter polymorphism of the interleukin-6 (IL-6) gene with endometriosis in South Indian women. METHODS: The genotype frequencies of the common IL-6 - 174 G/C polymorphism were compared in infertility patients with (h = 232) and without (n = 210) endometriosis using polymerase chain reaction (PCR) and sequencing analysis. RESULTS: The genotype frequencics among the cases and controls were G/G 62.9% and 71.9%, G/C 34.1% and 25.2%, and C/C 3.0% and 2.9%. The G and C allele frequencies were 80% and 84.6%, and 20% and 15.4%, respectively. There were no statistically significant differences in the genotype distributions or allele frequencies between the cases and controls (P =.12). CONCLUSIONS: The present study demonstrates no significant association between the IL-6 - 174 G/C promoter polymorphism and endometriosis in South Indian women.Copyright (c) 2005 by the Society for Gynecologic Investigation.