期刊
JOURNAL OF NEUROPHYSIOLOGY
卷 94, 期 1, 页码 699-711出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.01125.2004
关键词
-
资金
- NIMH NIH HHS [MH-59617] Funding Source: Medline
We tested the hypothesis that activation of nucleus basalis magnocellularis (NBM), which provides cholinergic input to cortex, facilitates motor control. Our measures of facilitation were changes in the direction and time-course of vibrissa movements that are elicited by microstimulation of vibrissa motor (M1) cortex. In particular, microstimulation led solely to a transient retraction of the vibrissae in the sessile animal but to a full motion sequence of protraction followed by retraction in the aroused animal. We observed that activation of NBM, as assayed by cortical desynchronization, induced a transition from microstimulation-evoked retraction to full sweep sequences. This dramatic change in the vibrissa response to microstimulation was blocked by systemic delivery of atropine and, in anesthetized animals, an analogous change was blocked by the topical administration of atropine to M1 cortex. We conclude that NBM significantly facilitates the ability of M1 cortex to control movements. Our results bear on the importance of cholinergic activation in schemes for neuroprosthetic control of movement.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据