期刊
ANNALS OF NEUROLOGY
卷 58, 期 1, 页码 147-150出版社
WILEY
DOI: 10.1002/ana.20524
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资金
- NIA NIH HHS [AG09464] Funding Source: Medline
Amyloid-beta (A beta) peptide levels are widely measured by enzyme-linked immunosorbent assay (ELISA) in Alzheimer's disease research. Here, we show that oligomerization of A beta results in underestimated A beta ELISA levels. The implications are that comprehensive analysis of soluble A beta requires either sample pretreatment at denaturing conditions or novel conformation-dependent immunoassays. Our findings might be of relevance for many neurodegenerative disorders in which soluble protein aggregates are the main neurotoxic species.
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