期刊
ONCOGENE
卷 24, 期 29, 页码 4701-4709出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1208391
关键词
PDGF; VEGF; angiogenesis inhibitors; tumorigenesis; growth factor binders
资金
- NCI NIH HHS [CA78038] Funding Source: Medline
- NIGMS NIH HHS [GM35208] Funding Source: Medline
Angiogenesis depends on vascular endothelial growth factor ( VEGF) for initiation and platelet-derived growth factor ( PDGF) for maintenance of blood vessels. We have designed a targeted library of compounds from which we identified a novel molecule, GFB-204, that binds PDGF and VEGF, blocks binding of PDGF and VEGF to their receptors (200-500 nM) and subsequently inhibits PDGFR and Flk-1 tyrosine phosphorylation and stimulation of the protein kinases Erk1, Erk2 and Akt and the signal transducer and activator of transcription STAT3. GFB204 is selective for PDGF and VEGF and does not inhibit EGF, IGF-1 and FGF stimulation of Erk1/2, Akt and STAT3. GFB-204 inhibits endothelial cell migration and capillary network formation in vitro. Finally, treatment of mice with GFB-204 suppresses human tumor growth and angiogenesis. Thus, inhibition of VEGF and PDGF receptor binding with a synthetic molecule results in potent inhibition of angiogenesis and tumorigenesis.
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