期刊
PHARMACOLOGICAL RESEARCH
卷 52, 期 1, 页码 83-92出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2005.02.012
关键词
poly(ADP-ribose) polymerase; asthma; silicosis; asbestosis; inflammation; oxidative stress; acute respiratory distress syndrome; allergy; peroxynitrite; cytokines; chemokines
Inhibition of poly(ADP-ribosyl)ation in oxidative stress-related pathologies has recently emerged as a very effective anti-inflammatory intervention in animal models of arthritis, colitis, diabetes and shock. Recent data from three laboratories also support the role of poly(ADPribose) polymerase-1 (PARP-1) activation in asthma. Similarly to other inflammatory conditions, the protective effects of PARP inhibition and the PARP-I knock out phenotype in asthma models have been attributed to inhibition of inflammatory signal transduction (mainly via NF-kappa B) and of oxidative stress-induced cell dysfunction and tissue injury. Here I discuss the complex role of poly(ADP-ribosyl)ation in the regulation of inflammatory cell migration, chemokine and cytokine production and expression of other inflammatory mediators (inducible nitric oxide synthase, matrix metalloprotemases) in asthma. The role of PARP-1 in other oxidative stress-related lung diseases such as asbestosis, silicosis, acute respiratory distress syndrome and ischemia-reperfusion injury is also reviewed. (c) 2005 Elsevier Ltd. All rights reserved.
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