期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 30, 期 7, 页码 396-404出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2005.05.008
关键词
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资金
- NIGMS NIH HHS [2R37 GM 32453] Funding Source: Medline
Phospholipid transport between membranes is a fundamental aspect of organelle biogenesis in eukaryotes; however, little is know about this process. A significant body of data demonstrates that newly synthesized phospholipids can move between membranes by routes that are independent of the vesicular traffic that carries membrane proteins. Evidence continues to accumulate in support of a system for phospholipid transport that occurs at zones of apposition and contact between donor membranes - the source of specific phospholipids - and acceptor membranes that are unable to synthesize the necessary lipids. Recent findings identify some of the lipids and proteins that must be present on membranes for inter-organelle phospholipid transport to occur between the endoplasmic reticulum and mitochondria or Golgi. These data suggest that protein and lipid assemblies on donors and acceptors promote membrane docking and facilitate lipid movement.
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