Chemiluminescence micro-flow-injection analysis on a chip

Chemiluminescence microflow-injection analysis (mu FIA) systems on a chip have been developed. The technology of laser ablation was used to fabricate the microchannels on the polymethyl methacrylate (PMMA) chip. The three sampling structure, including double-tee sampling structure, microvalve sampling structure and injection pump with accurate time control, were used. The microcolumn for specific molecular recognition, including molecularly imprinted polymer, enzyme and bacteria, were used to enhance selectivity. These mu FIA systems have been applied to clinical analysis, assessment of food safety, in vivo and real-time determination of drugs, and pharmacokinetics studies. Copyright (c) 2005 John Wiley & Sons, Ltd.