Microfabrication of multilayer, asymmetric, polymeric devices for drug delivery

Multilayered, asymmetric vehicles have been constructed with 3D features that may provide the capacity to target cells, promote unidirectional controlled release, and enhance permeation across the intestinal epithelial barrier. The Figure shows microfabricated PMMA devices and their specific interactions (postchemical surface modification) with a human colonic cell line expressing enterocytic differentiation.