期刊
FEBS LETTERS
卷 579, 期 17, 页码 3560-3564出版社
WILEY
DOI: 10.1016/j.febslet.2005.05.028
关键词
nuclear receptor; chemical carcinogenesis; transactivation; phenobarbital-responsive enhancer module
Phenobarbital (PB) induction of CYP2B, a representative target gene of constitutive androstane receptor (CAR), has been observed to be attenuated in preneoplastic lesions of rat liver; however, molecular basis for this attenuation is poorly understood. In this report, we provide evidence indicating that the CAR expressed in the hepatic preneoplastic lesions of rats and mice was resistant to nuclear translocation and transactivation of the PB-responsive enhancer module upon PB treatment. These observations suggest that the attenuation of the induction of CYP2B by PB in hepatic preneoplastic lesions is evidently a consequence of impaired nuclear translocation of CAR. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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