期刊
JOURNAL OF NEUROSCIENCE
卷 25, 期 27, 页码 6372-6378出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1851-05.2005
关键词
motor cortex; sensorimotor; motor learning; motor control; learning and memory; repetitive transcranial magnetic stimulation
资金
- NCRR NIH HHS [RR018875, K24 RR018875] Funding Source: Medline
- NIMH NIH HHS [K23 MH065434, MH-65434] Funding Source: Medline
We are all familiar with acquiring skills during practice, but skill can also continue to develop between practice sessions. These off-line improvements are frequently supported by sleep, but they can be time dependent when a skill is acquired unintentionally. The magnitude of these over-day and overnight improvements is similar, suggesting that a similar mechanism may support both types of off-line improvements. However, here we show that disruption of the primary motor cortex with repetitive transcranial magnetic stimulation blocks off-line improvements over the day but not overnight. This suggests that a memory may be rescued overnight and subsequently enhanced or that different aspects of a skill, with differential dependencies on the primary motor cortex, are enhanced over day and overnight. Off-line improvements of similar magnitude are not supported by similar mechanisms; instead, the mechanisms engaged may depend on brain state.
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