期刊
ORGANIC LETTERS
卷 7, 期 14, 页码 3009-3012出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol050980y
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资金
- NIGMS NIH HHS [GM 064559] Funding Source: Medline
We describe the diastereoselective synthesis of a pharmaceutically active drug candidate via a column-based system. This methodology is complementary to classical solid-phase synthesis; individual columns are packed with resin-bound reagents and then linked in sequence and/or in parallel. In contrast to the traditional solid-phase approach, substrates are introduced in the mobile phase where they build up chemical complexity by percolating through the linked columns, ultimately eluting as the desired product.
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