期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 70, 期 14, 页码 5636-5642出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo050640q
关键词
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The two-step metal-catalyzed overall transformation of isoxazolidine-5-spirocyclopropanes into the corresponding dihydro- and tetrahydropyridones is described. The first step is the chemoselective reduction of the N-O bond of the isoxazolidine ring preserving the fragile cyclopropanol moiety while the second transformation is the Pd(II) or Pd(O) conversion of the beta-aminocyclopropanol derivatives into the final compounds. The scope and limitations of this strategy are described.
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