期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2005, 期 14, 页码 3101-3115出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200400911
关键词
asymmetric synthesis; biocatalytic resolution; inositol phosphates; natural products; phosphorylation; protecting groups
A practical route is described for the preparation of myo-inositol polyphosphates. Optically pure myo-mositol derivatives can be prepared from p-benzoquinone in both forms by enzymatic resolution of a C-2-symmetric diacetoxyconduritol B key intermediate, followed by cis-dihydroxylation. Selective functionalization of axial and equatorial hydroxy groups allows the synthesis of symmetric mositol phosphates as well as unsymmetrical, enantiomerically pure mositol phosphates. (c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.
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