期刊
BIOSENSORS & BIOELECTRONICS
卷 21, 期 1, 页码 212-216出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2004.08.020
关键词
polyelectrolyte multilayers; microspheres; optical glucose sensors
类别
资金
- NIBIB NIH HHS [R01 EB000739-02, R01 EB000739, R01 EB000739-03] Funding Source: Medline
Microspheres coated with polyelectrolyte multilayers (PEM's) are being investigated for potential use as implantable biosensors-so-called smart tattoos. In this work, the feasibility of this approach for glucose sensors was demonstrated by glucose oxidase encapsulated within calcium alginate microspheres, followed by entrapment of an oxygen-quenched ruthenium compound in the same microstructure. A novel feature of these microdevices is the formation of multilayer nanofilms on the surface of the microspheres, used to stabilize enzyme entrapment and control substrate diffusion. Confocal microscopy was used to confirm the stable encapsulation of sensor chemistry. The reversible response of sensors to step changes in glucose was observed, and preliminary experimental data were compared to theoretical predictions produced by a computational model. These findings demonstrate the promise of the described nanoengineering approach for production of functional implantable glucose sensor materials. (c) 2004 Elsevier B.V. All rights reserved.
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