An improved synthesis of 5′-fluoro-5′-deoxyadenosines

Synthesis of 5'-fluoro-5'-deoxyadenosine (5'-FDA) and structurally similar compounds is generally a poor yielding process. This is attributed to the instability of the selected synthetic intermediates. Herein, we report a general synthesis of 5'-fluoro-5'-deoxy-N-6-substituted adenosines including a high yielding access to 5'-FDA. (c) 2005 Elsevier Ltd. All rights reserved.