期刊
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
卷 80, 期 19, 页码 6080-6090出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.01993-14
关键词
-
资金
- Laboratory of Probiogenomics
- FEMS Jensen Award
- Science Foundation Ireland (SFI) through the Irish Government's National Development Plan [07/CE/B1368, SFI/12/RC/2273, 08/SRC/B1393]
Bifidobacteria are members of the gut microbiota, but the genetic basis for their adaptation to the human gut is poorly understood. The analysis of the 2,203,222-bp genome of Bifidobacterium adolescentis 22L revealed a nutrient acquisition strategy that targets diet/plant-derived glycans, in particular starch and starch-like carbohydrates. Starch-like carbohydrates were shown to support the growth of B. adolescentis 22L. Transcriptome profiling of 22L cultures grown under in vitro conditions or during colonization of the murine gut by RNA sequencing and quantitative real-time PCR assays revealed the expression of a set of chromosomal loci responsible for starch metabolism as well as for pilus production. Such extracellular structures include so-called sortase-dependent and type IVb pili, which may be involved in gut colonization of 22L through adhesion to extracellular matrix proteins.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据