期刊
FEBS LETTERS
卷 579, 期 18, 页码 3975-3978出版社
WILEY
DOI: 10.1016/j.febslet.2005.06.024
关键词
cytosolic phospholipase A2 alpha; non-obese diabetic mouse; prostaglandin E2; T-helper 1; TNF-alpha; type 1 diabetes
Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) plays an important role in arachidonate pathway. To investigate the contribution of cPLA(2)alpha to autoimmune diabetes, we established non-obese diabetic (NOD) mouse, an excellent model for human type 1 diabetes, deficient in ePLA(2)alpha. These mice showed severe insulitis and a higher incidence of diabetes. In their macrophages, decreased prostaglandin E-2 (PGE(2)) induced by cPLA(2)alpha deficiency, and the increase in production of tumor necrosis factor (TNF)-alpha were observed. These results suggested that cPLA(2)alpha plays a protective role in progression of insulitis and development of autoimmune diabetes by suppression of TNF-alpha production from macrophages. (c) 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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