期刊
FEBS LETTERS
卷 579, 期 18, 页码 3907-3912出版社
WILEY
DOI: 10.1016/j.febslet.2005.06.008
关键词
calcium channels; N-type; T-type; ion channel gating; structure-activity relationship
资金
- NINDS NIH HHS [NS38691] Funding Source: Medline
High voltage-activated Ca2+ channel expression and gating is controlled by their beta subunits. Although the sites of interaction are known at the atomic level, how beta modulates gating remains to be determined. Using a chimeric approach, beta subunit regulation was conferred to a low voltage-activated channel. Regulation was dependent on a rigid linker connecting the a, interaction domain to IS6. Chimeric channels also revealed a role for IS6 in channel gating. Taken together, these results support a direct coupling model where beta subunits alter movements in IS6 that occur as the channel transits between closed, open, and inactivated states. (c) 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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