期刊
BRAIN RESEARCH
卷 1050, 期 1-2, 页码 8-14出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2005.05.025
关键词
nucleus accumbens; drug abuse; cocaine; neuropeptides
资金
- NCRR NIH HHS [RR00165] Funding Source: Medline
- NIDA NIH HHS [DA015040, DA00418, DA10732] Funding Source: Medline
CART peptide is a novel neurotransmitter that, due to its distribution in the brain and its modulation of dopamine systems, may be involved in aspects of reward and drug abuse. In the nucleus accumbens (NAcc), CART peptide immunoreactivity (IR) is colocalized with substance P-IR in neurons. Approximately 86% of CART-IR cells colocalize with substance P, while only 19% of substance P-IR neurons contain CART. CART peptide does not colocalize with enkephalin-IR in this region. The substance P-CART colocalization exists in a rostrocaudal gradient with more colocalization in rostral regions. The presence of CART in substance P NAcc neurons suggests that CART neurons may be a subset of the basal ganglia direct pathway or that CART neurons are involved in limbic projections of the NAcc, such as to the ventral pallidum. (C) 2005 Elsevier B.V. All rights reserved.
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