4.8 Article

Synthesis of fused bicyclic imidazoles by sequential van Leusen/ring-closing metathesis reactions

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ORGANIC LETTERS
卷 7, 期 15, 页码 3183-3186

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AMER CHEMICAL SOC
DOI: 10.1021/ol050852+

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A new strategy employing the van Leusen three-component reaction and the ring-closing metathesis reaction in a sequential fashion to access fused bicyclic imidazole rings is reported. The two-step sequence generated compounds of significant molecular complexity from simple starting materials in an expedient fashion with excellent yields.

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