The clinical application of proteomics

Background: Proteomics is defined as a scientific approach used to elucidate all protein species within a cell or tissue, and many researchers are taking advantage of proteomic technology to elucidate protein changes between healthy and diseased states. Methods: The application of proteomic techniques and strategies to the field of medicine is slowly transforming the way biomarker discovery is conducted. However, the complexity of serum is the source of both its promise to clinical applications and its challenge to proteomic analysis. Like any new technology when it is first introduced, proteomics has been touted with much hope and promise. Results and conclusions: We provide a review of the clinical application of proteomics with the emphasis on current practical issues and challenges facing proteomic research. (c) 2005 Elsevier B.V All rights reserved.