期刊
CARBOHYDRATE RESEARCH
卷 340, 期 10, 页码 1722-1731出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carres.2005.04.013
关键词
heparin disaccharide; gangliosides; MALDI-TOFMS
New two-component systems using quaternary ammonium or phosphoniurn salts as a co-matrix have been developed for the analysis of acidic carbohydrates by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS). In the analysis of the sodium salt of heparin disaccharide I-S, the combination of 2-amino-5-nitropyridine with tetraphenylphosphonium bromide gave the best result. In the analysis of gangliosides containing the sialic acid moiety, the combination of 2,4,6-trihydroxyacetophenone with dimethyldipalmitylammonium bromide was determined to be the system of choice. Under optimum conditions all acidic carbohydrates gave molecular ions in the form of [M(Q(n))-Q](-), where M(Q(n)) is the molecular mass of a molecule containing n molecules of quaternary ions as salt. (c) 2005 Elsevier Ltd. All rights reserved.
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